Survivin Monoclonal Antibody (32.1)

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Description Size Catalog# Price Quantity  
Survivin Monoclonal Antibody (32.1) 100 µg  905-627 $285.00
Background
Survivin is a 16.5 kDa protein and the smallest inhibitor of apoptosis (IAP) so far identified. It is involved in the inhibition of apoptosis and cell division. Survivin expression has been reported at high levels in embryonic tissues, but at low or non-detectable levels in normal tissue. Survivin regulates the G2/M phase of the cell cycle by associating with the mitotic spindle microtubules and directly inhibits Caspase-3 and Caspase-7. Survivin is selectively expressed in the most common human cancers and is associated with clinical tumor progression. It has been proposed as a tumor marker for breast cancer, and Survivin expression has been correlated to clinical outcome in melanoma patients. Down-regulation or loss of Survivin is thought to inhibit the growth of tumor cells. Further, it has been indicated that Survivin epitopes may serve as important targets for anticancer immunotherapy approaches, and that Survivin is a rational target for apoptosis-based cancer therapy. It has also been proposed that Survivin may be used as a universal tumor antigen for immunotherapy.

Table of Abbreviations

Abbreviated Name
Survivin mAb (32.1)

Conjugate

Applications
Flow, WB

Isotype
IgG1

Purification
Protein G Affinity

Immunogen
Recombinant human Survivin protein (full length)

Host
Mouse

Clone Number
32.1

Species Reactivity
H

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
Survivin Polyclonal Antibody
 		AAP-275

Citations
Launch Citation Database

Ordering Info
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