BCMA Polyclonal Antibody

Product Comments
Members of the TNF superfamily regulate immune responses and induce apoptosis. Two novel members of this family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF41-4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors for BAFF, BCMA (B cell maturation protein), TACI, and BAFF-R, were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

Applications
IHC, WB

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HostSpecies
rabbit

Immunogen
Synthetic peptide derived from sequence near the carboxy-terminus of human BCMA

PositiveControls
Human spleen tissue lysate, K562 and U937 cell lysates

PurificationMethod
Affinity purified

Species Reactivity
H

For research use only, not for diagnostic or therapeutic use.