BAFF-R (CT) BR3 Polyclonal Antibody

Product Comments
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF41-4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion1,2. Two receptors, TACI and BCMA, for BAFF were originally identified5. A third receptor was identified and designated BAFF-R and BR3 for BLyS receptor 36,7. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-¿B and c-jun N-terminal kinase4-6.

Applications
IHC, WB

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HostSpecies
rabbit

Immunogen
Synthetic peptide derived from sequence near the carboxy-terminus of human BAFF-R

PurificationMethod
Affinity purified

Species Reactivity
H, M, R

For research use only, not for diagnostic or therapeutic use.