IL-1beta Monoclonal Antibody

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Description Size Catalog# Price Quantity  
IL-1beta Monoclonal Antibody 500 µg  905-100 $295.00
Background
The interleukin-1 (IL-1) cytokine family consists of IL-1alpha, IL-1beta, and IL-1Ralpha (receptor antagonist) which are expressed primarily by endothelial cells and activated macrophages. IL-1alpha and IL-1beta elicit pro-inflammatory cytokine production and cellular activation, and are the primary mediators of hypothalamic regulation that results in fever. IL-1alpha and IL-1beta signals are transmitted via a dual subunit IL-1 receptor composed of IL-1R1 and the IL-1 receptor accessory protein (IL-1RAcP). IL-1RAcP is vital to IL-1 signaling, as it recruits the IL-1 receptor-associated kinase (IRAK) to the receptor complex, initiating NF-kappaB pathway activation.

Table of Abbreviations

Applications
EIA, IA

Format
Lyophilized in PBS

CloneNumber
NYR-hIL1b

HostSpecies
mouse

Immunogen
Recombinant human Interleukin-1beta

Isotype
mouse IgG2b

PurificationMethod
Protein A

Species Reactivity
H

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

Related Products

Product Name Catalog#
MyD88 Polyclonal Antibody
 		CSA-510

Citations
Launch Citation Database

Ordering Info
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