5,6-dihydro PGI2 Polyclonal Antibody

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Description Size Catalog# Price Quantity  
5,6-dihydro PGI2 Polyclonal Antibody 100 µL  905-048 $230.00
Background
Prostacyclin (PGI2) is involved in platelet aggregation, vasoconstriction, and reproductive functions. PGI2 has a half life of 60 minutes in plasma but only 2 to 3 minutes in buffer. The production of PGI2 is typically monitored by measurement of 6-keto-PGF1alpha and 2,3-dinor-6-keto-PGF1alpha. 6-keto-PGF1alpha is produced by the non-enzymatic hydration of PGI2, and is further metabolized in urine to the 2,3-dinor derivative. A number of pharmaceuticals alter and/or inhibit the synthesis of PGI2. Methods to measure PGI2 in urine typically involve HPLC, gas chromatography/mass spectrometry, or radioimmunoassay and enzyme immunoassay for 6-keto-PGF1alpha. The conversion of PGI2 into 6-keto-PGF1alpha and 2,3-dinor-6-keto-PGF1alpha is shown below.

Table of Abbreviations

Species Reactivity
Species Independent

Applications
EIA

Cross Reactivities
5,6-dihydro-PGI2 100%
PGF2a 3.00%
6-keto-PGF1a 1.30%
PGE2 1.30%
PGF1a 1.00%
PGE1 0.70%

HostSpecies
rabbit

Immunogen
5,6-dihydro-Prostaglandin I2 conjugated to human albumin

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

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Citations
Launch Citation Database

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