Leukotriene C4/D4/E4/F4 Antibody

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Description Size Catalog# Price Quantity  
Leukotriene C4/D4/E4/F4 Antibody lyoph  905-038 $65.00
Background
Leukotrienes are major products of 5-lipoxygenase metabolism of arachidonic acid. Leukotriene B4 (LTB4) stimulates leukocyte functions including lysosomal enzyme release, adhesion, and aggregation of polymorphonuclear leukocytes. LTB4 has been implicated as a potent mediator of inflammatory diseases and immunoregulation. The cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are formed by addition of cysteine derivatives to LTA4. The conversion of LTA4 to LTC4 by the enzyme LTC4 synthase limits the rate of cysteinyl leukotriene formation. Cysteinyl leukotrienes are potent lipid mediators in inflammation, inducing smooth muscle contractions and increased capillary permeability.

Table of Abbreviations

Species Reactivity
Species Independent

Applications
EIA

Format
antisera

Cross Reactivities
LTD4 100%
LTF4 66.7%
LTC4 55.0%
LTE4 51.0%
LTB4 0.25%
5-HETE 0.19%
Linoleic acid 0.12%
Arachidonic acid 0.12%
<0.01%: PGA2, PGB2, PGD2, PGE1, PGE2, PGF1a, PGF2a, 6-keto-PG1a, 13,14-dihydro-15-keto-PGF2a, 13,14-dihydro-15-keto-PGE2, TXB2, <0.003%: L-cysteine, Glutathione (ox), Glutathione (red), Palmitic acid

HostSpecies
mouse

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

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Product Name Catalog#

Citations
Launch Citation Database

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