PGE2 High Sensitivity EIA Kit

Brand: Assay Designs

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Description	Size	Catalog#	Price	Quantity
PGE2 High Sensitivity EIA Kit	1x96 well	930-001	$335.00
PGE2 High Sensitivity EIA Kit	5x96 well	931-001	$1,395.00

Background

Prostaglandin E2 (PGE2) is an extensively studied prostaglandin owing to its predominance in inflammation, cancer, atherosclerosis, autoimmune disease, and sepsis. Oxidation of arachidonic acid by prostaglandin synthases (COX-1 and COX-2) produces prostaglandin H2 (PGH2), which is further metabolized by PGE synthases into its major product, PGE2. PGE2 mediates autocrine and paracrine signaling by binding to G-protein coupled receptors (EP1, EP2, EP3, EP4) on the cell surface, functioning to modulate phospholipase C and adenylate cyclase activity. PGE2 has been of great interest as a therapeutic target, either by modulation of its synthesis by COX inhibitors (NSAIDS) or by modulation of its receptors by downregulation or binding antagonists. PGE2 production in a variety of tissues has been shown to modulate numerous physiological processes including natriuresis in the kidney, smooth muscle elasticity in the vasculature, and the inflammatory response to damaged tissues by monocytes and macrophages.

Table of Abbreviations

Applications
EIA

Format
ELISA

Features

Validated in numerous sample matrices
Highly cited in peer reviewed literature

Range
7.8 - 1,000 pg/mL

Sample Size
100 無

Product Image(s): click to enlarge

Cross Reactivities
PGE2 100%
PGE1 70.0%
PGE3 16.3%
PGF1alpha 1.40%
PGF2alpha 0.70%
6-keto-PGF1alpha 0.60%
PGA2 0.10%
PGB1 0.10%
<0.10%: 13,14-dihydro-15-keto-PGF2alpha / 6,15-keto-13,14-dihydro-PGF1alpha / Thromboxane B2 / 2-Arachidonoylyglycerol / Anandamide / PGD2 / Arachidonic Acid

Sample Types
culture media, saliva, serum, urine, whole blood

Samples Per Kit
36 in duplicate per 96 well kit

Sensitivity
8.26 pg/mL

Species Reactivity
Species Independent

Time To Answer
overnight

For research use only, not for diagnostic or therapeutic use.

Documentation
AssayLayout

Product Manual

Product Name	Catalog #	Manual
PGE2 High Sensitivity EIA Kit	930-001	Kit Insert MSDS
PGE2 High Sensitivity EIA Kit	931-001	Kit Insert MSDS

Related Products

Product Name	Catalog#
COX Activity Kit	907-003
Creatinine Colorimetric Detection Kit	907-030
PGE2 CLIA Kit	910-001
PGE2 EIA Kit	900-001
PGE2 EIA Kit	901-001
PGE2 FPIA Kit	920-001
Prostaglandin E2 Monoclonal Antibody (BG8)	905-628
TXB2 EIA Kit	900-002

Citations
Launch Citation Database

Ordering Info
Click here to learn more about online ordering
Order by phone: 734-668-6113 or 877-423-4548
Order by e-mail: orders@assaydesigns.com
Order by fax: 734-669-0134

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PGE2 High Sensitivity EIA Kit