PGE2 FPIA Kit

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Description Size Catalog# Price Quantity  
PGE2 FPIA Kit 100 tests  920-001 $225.00
Background
Prostaglandin E2 (PGE2) is an extensively studied prostaglandin owing to its predominance in inflammation, cancer, atherosclerosis, autoimmune disease, and sepsis. Oxidation of arachidonic acid by prostaglandin synthases (COX-1 and COX-2) produces prostaglandin H2 (PGH2), which is further metabolized by PGE synthases into its major product, PGE2. PGE2 mediates autocrine and paracrine signaling by binding to G-protein coupled receptors (EP1, EP2, EP3, EP4) on the cell surface, functioning to modulate phospholipase C and adenylate cyclase activity. PGE2 has been of great interest as a therapeutic target, either by modulation of its synthesis by COX inhibitors (NSAIDS) or by modulation of its receptors by downregulation or binding antagonists. PGE2 production in a variety of tissues has been shown to modulate numerous physiological processes including natriuresis in the kidney, smooth muscle elasticity in the vasculature, and the inflammatory response to damaged tissues by monocytes and macrophages.

Table of Abbreviations

Applications
FPIA

Features

  • Easy to use, homogeneous format
  • Results in just 30 minutes

Range
1,562 - 100,000 pg/mL

Sample Size
100 µL/96 well, 40 µL/384 well

Product Image(s): click to enlarge

Cross Reactivities
PGE2 100%
PGE1 100%
PGD2 11%
PGF2alpha 2.5%
6-keto-PGF1alpha 2.3%
PGB2 1.8%
PGI2 0.9%
TXB2 0.3%
<0.10%: Arachidonic Acid / Dihomo-gamma-linolenic acid

Sample Types
cell supernatants

Samples Per Kit
100 tests at 100 µL

Sensitivity
684 pg/mL

Species Reactivity
Species Independent

Time To Answer
minimum of 30 minutes

Z Factor
0.88

For research use only, not for diagnostic or therapeutic use.

Documentation
Kit Insert
MSDS

Related Products

Product Name Catalog#
COX Activity Kit
 		907-003
PGE2 CLIA Kit
 		910-001
PGE2 EIA Kit
 		900-001
PGE2 EIA Kit
 		901-001
PGE2 High Sensitivity EIA Kit
 		930-001
PGE2 High Sensitivity EIA Kit
 		931-001
PGE2 Monoclonal Antibody (BG8)
 		905-628
TXB2 EIA Kit
 		900-002

Citations
Launch Citation Database

Ordering Info
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