COX Activity Kit

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Description Size Catalog# Price Quantity  
COX Activity Kit 1x96 well  907-003 $320.00
Background
Cyclooxygenase (COX, also known as Prostaglandin G/H synthase) is a membrane bound enzyme responsible for the oxidation of arachidonic acid to Prostaglandin G2 (PGG2) and the subsequent reduction of PGG2 to PGH2. These reactions are the first steps in the formation of a variety of prostanoids. COX has been shown to be expressed in at least two different isoforms: a constitutively expressed form, COX-I, and an inducible form, COX-II. COX-I is thought to regulate a number of 'housekeeping' functions, such as vascular hemostasis, renal blood flow, and maintenance of glomerular function. Inflammation mediators such as growth factors, cytokines and endotoxin induce COX-II expression in a number of cellular systems. The effect of various non-steroidal anti-inflammatory drugs (NSAIDs) on the activity of COX-I and -II is an area of considerable interest.

Format
Detection Kit

Features

  • Much less time consuming than conventional testing methods
  • Completely customizable by the end user
  • Excellent sensitivity and suitable for high throughput analysis

Range
7.5 - 60 Units/mL

Sample Size
50 µL

Product Image(s): click to enlarge

Samples Per Kit
40 in duplicate per 96 well kit

Sensitivity
0.147 Units/mL COX-I

Significance and Uses
The Chemiluminescent Cyclooxygenase Activity kit is for the quantitative determination of Cyclooxygenase activity in biological samples. Sample types include buffers.

Species Reactivity
Species Independent

Applications
Activity

For research use only, not for diagnostic or therapeutic use.

Documentation
Kit Insert
MSDS

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Citations
Launch Citation Database

Ordering Info
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