COX-II (human) EIA Kit

Product Comments
The human COX-II enzyme immunometric assay kit is a complete kit for the quantitative determination of COX-II in cell culture lysates.

Applications
EIA

Format
ELISA

Features

• Most sensitive COX-II immunoassay kit on the market
• Results in just 2 hours

Range
2.15 - 137.5 ng/mL

Sample Size
100 µL

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Cross Reactivities
human COX-II 100%
human COX-I <0.1%

Sample Types
TNE buffer

Samples Per Kit
39 in duplicate per 96 well kit

Sensitivity
0.249 ng/mL

Significance and Uses
Cyclooxygenase (COX) is a membrane bound enzyme responsible for the oxidation of arachidonic acid to Prostaglandin G2 (PGG2) and the subsequent reduction of PGG2 to PGH2. These reactions are the first steps in the formation of a variety of prostanoids. COX has been shown to be expressed in at least two different isoforms, a constitutively expressed form, COX-I, and an inducible form, COX-II. COX-I is thought to regulate a number of "housekeeping" functions, such as vascular hemostasis, renal blood flow, and maintenance of glomerular function. Inflammation mediators such as growth factors, cytokines and endotoxin induce COX-II expression in a number of cellular systems. The Assay Designs human COX-II kit is a complete kit for the quantitative determination of human COX-II in cell culture lysates.

Species Reactivity
H

Time To Answer
2 hours

For research use only, not for diagnostic or therapeutic use.