PEN2 Polyclonal Antibody

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Description Size Catalog# Price Quantity  
PEN2 Polyclonal Antibody 100 µg  905-736-100 $295.00
Background
PEN2, in addition to nicastrin, presenilin, and APH-1, forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is thought to be required for the generation of neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer?s disease. Gamma- secretase will cleave the amyloid precursor protein (APP) within the intramembrane region, resulting in either the nontoxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site).

Table of Abbreviations

Applications
WB

Product Image(s): click to enlarge

Species Reactivity
H, M, R

Format
PBS, 0.02% sodium azide

Host Species
Rabbit

Immunogen
Synthetic peptide corresponding to a sequence near the amino-terminus of human PEN2

Positive Control
A20 cell lysates

Purification Method
Peptide Affinity

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
APP Monoclonal Antibody (3E9)
 		NBA-100E
APP Polyclonal Antibody
 		NBA-102
Amyloid beta Monoclonal Antibody (2C8)
 		NBA-104E
Nicastrin Polyclonal Antibody
 		905-737-100

Citations
Launch Citation Database

Ordering Info
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