Huntingtin Interacting Protein-1 Monoclonal Antibody (4B10)

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Description Size Catalog# Price Quantity  
Huntingtin Interacting Protein-1 Monoclonal Antibody (4B10) 100 µg  905-133 $295.00
Background
Huntingtin interacting protein 1 (HIP-1) is a 116 kDa cytosolic protein. It acts as a co-factor in clathrin-mediated endocytosis. HIP-1 is a prognostic marker for breast, prostate and colorectal cancer. It is an especially effective marker for prostate cancer, where differences in tissue are often difficult to detect. Lack of tissue HIP-1 expression has been shown to provide a survival advantage in prostate cancer patients. In addition, the degree of tissue HIP-1 staining is correlated with tumor aggressiveness and patient survival. HIP-1 also has oncogenic properties and can transform certain types of fibroblasts. HIP-1 expression promotes cell proliferation and increases cell density.

Table of Abbreviations

Conjugate

Applications
EIA, IHC, WB

Isotype
IgG1

Purification
Protein G Affinity

Immunogen
Recombinant Huntingtin Interacting Protein-1 (carboxyl terminal fragment)

Host
Mouse

Clone Number
4B10

Cross Reactivities
Recognizes amino acids 750-780 of human HIP-1 but does not react with mouse HIP-1.

Species Reactivity
H

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
Huntingtin Interacting Protein-1 Monoclonal Antibody (1B11)
 		905-134

Citations
Launch Citation Database

Ordering Info
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