Rapamycin, Inhibitor

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Rapamycin, Inhibitor 1mg  HPK-109J $175.00
Background
Rapamycin is a macrocyclic lactone antibiotic produced by Streptomyces hygroscopicus that was originally developed as an anti-fungal drug, but utilized most recently as an anti-cancer and immunosuppressive agent. Rapamycin binds the immunophilin FK506 binding protein (FKBP12) via its methoxy group, enabling this complex to inhibit mTOR (molecular Target Of Rapamycin)-TORC1 signaling complexes. Inhibition of mTOR by rapamycin prevents phosphorylation of downstream mTOR substrates, including key regulators of apoptosis, transcription and translation such as eEF2, p70 S6K, and 4E-BP1.

Table of Abbreviations

Abbreviated Name
Rapamycin, Inhibitor

Species Reactivity
Species Independent

Applications
FK506 binding protein Inhibition

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
p70 S6K Recombinant Human Protein
 		PPK-439

Citations
Launch Citation Database

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