c-Kit Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
c-Kit Polyclonal Antibody 100 µg  KAP-TK005E $285.00
Background
c-Kit, also known as CD117 and Stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit protooncogene. c-Kit regulates a variety of biological responses including cell proliferation, apoptosis, chemotaxis, and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer.

Table of Abbreviations

Abbreviated Name
c-Kit pAb

Conjugate

Applications
IHC, WB

Isotype
not applicable

Purification
Immunoaffinity

Immunogen
Synthetic peptide derived from sequence near the carboxy-teminus of human c-Kit, conjugated to bovine thryoglobulin. This sequence shares 92% identity with canine c-Kit and 83% identity with mouse and rat.

Host
Rabbit

Clone Number
not applicable

Species Reactivity
H

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#

Citations
Launch Citation Database

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