c-Met Polyclonal Antibody

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Description Size Catalog# Price Quantity  
c-Met Polyclonal Antibody 100 µg  905-076 $295.00
Background
Binding of Scatter factor (SF)/Hepatocyte growth factor (HGF) to the c-Met receptor tyrosine kinase (RTK) triggers receptor dimerization and phosphorylation on multiple residues within the juxtamembrane, catalytic core and cytoplasmic tail domains, thereby regulating receptor internalization, catalytic activity and multisubstrate docking. Activation of the c-Met receptor results in binding and/or phosphorylation of many intracellular signaling proteins including multiple adaptor proteins (e.g., Grb2, Shc, Cbl, Crk, Cortactin, Paxillin, and GAB1), and a variety of other signal transducers (e.g., PI 3-kinase, FAK, Src, Erk1/2, Jnk, PLC-gamma, and Stat3).

Table of Abbreviations

Applications
IHC, WB

Format
Lyophilized in PBS (p7.4) containing 1% BSA and 0.05% NaN3

Cross Reactivities
Reacts to c-Met beta chain

HostSpecies
rabbit

Immunogen
Synthetic peptide derived from sequence near the carboxy-terminus of human c-Met beta

Isotype
rabbit IgG

PurificationMethod
Peptide Affinity

Species Reactivity
H

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

Related Products

Product Name Catalog#
HGF/SF Monoclonal Antibody (7-2)
 		905-165
HGF/SF Monoclonal Antibody (A10)
 		905-163
MET/HGFR (phospho-Tyr1234/1235) Monoclonal Antibody (6AT1877)
 		905-696-100
Rabbit IgG Polyclonal Antibody, HRP Conjugate
 		SAB-300
c-Met (phospho-Tyr1230/1234/1235) Polyclonal Antibody
 		KAP-TK010E

Citations
Launch Citation Database

Ordering Info
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