12-HETE Polyclonal Antibody

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Description Size Catalog# Price Quantity  
12-HETE Polyclonal Antibody lyoph  905-032 $115.00
Background
HETEs are byproducts generated by the metabolism of arachidonic acid by lipoxygenases. 12(S)-HETE is the stereospecific hydroxy product from the reduction of 12(S)-hydroperoxy tetraenoic eicosatetraenoic acid [12(S)-HpETE], which itself is a 12-lipoxygenase metabolite of arachidonic acid. 12(S)-HETE is chemotactic and chemokinetic for polymorphonuclear leukocytes and vascular smooth muscle cells. It also acts as a second messenger in angiotensin-II induced aldosterone production. 15-hydroxyeicosatetraenoic acid [15(S)-HETE] is the major hydroxy derivative of arachidonic acid when acted upon by 15-lipoxygenase. It is also the primary monohydroxy acid synthesized by the lipoxygenase activity of Cyclooxygenase-1 upon linoleic acid. 15(S)-HETE acts as a paracrine regulator of smooth muscle and lung neutrophil recruitment, and elevated levels of 15(S)-HETE are associated with asthma, rhinitis, chronic paranasal sinusitis and rheumatoid arthritis.

Table of Abbreviations

Species Reactivity
Species Independent

Applications
EIA

Format
antisera

Cross Reactivities
12-HETE 100%
15-HETE 0.30%
5-HETE 0.20%
0.10%: 8,15-DiHETE, 5,15-DiHETE, PGE2, PGF2a, PGD2, 6-keto-PGF1a, TXB2, Arachidonic acid

HostSpecies
rabbit

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

Related Products

Product Name Catalog#
12(S)-HETE EIA Kit
 		900-050
12(S)-HETE EIA Kit
 		901-050

Citations
Launch Citation Database

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