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Adrenergic Receptor (beta 1) Polyclonal Antibody

Brand: Proteimax Print Page
Description Size Catalog# Price Quantity  
Adrenergic Receptor (beta 1) Polyclonal Antibody 100 µg   905-784-100 $285.00
Background
Adrenergic receptors mediate the hormone and neurotransmitter functions of adrenaline and noradrenaline. Adrenoreceptors function in peripheral tissues and the central nervous system to regulate numerous vascular, metabolic, and neurological functions, and are the target for many therapeutically relevant drugs including those for the treatment of hypertension, asthma, benign prostatic hypertrophy, and depression1. Adrenoreceptors are classified by three types (alpha 1, alpha 2, and beta) and multiple subclasses based on pharmacological and molecular characteristics. The three beta adrenergic receptor subtypes (beta 1, 2, 3) signal primarily via coupling to GS alpha subunits, stimulating production of cAMP and activation of protein kinase A to regulate opening of L-type Ca2+ channels. Expression of beta 1 receptors is highest in the heart and in adipose tissue, displaying relatively equal sensitivity to adrenaline and noradrenaline. The beta 2 receptor mediates relaxation in vascular, uterine, and pulmonary smooth muscle, and shows greater sensitivity to noradrenaline compared to adrenaline. Agonist affinity to beta 2 adrenergic receptors is modulated by Zn2+ concentration, and may also trigger cGMP accumulation and protein kinase G activation via Gi/o alpha subunit coupling in some cell types.

Table of Abbreviations

Applications
WB, Membrane ELISA

Species Reactivity
R (H, M)

Shipping Information
Please allow 15 working days for delivery.

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from sequence near the amino-terminus of rat Adrenergic Receptor (beta 1)

Host
Rabbit

Product Image(s): click to enlarge

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

Ordering Info
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