Neurofilament Monoclonal Antibody (DP5-112)

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Description Size Catalog# Price Quantity  
Neurofilament Monoclonal Antibody (DP5-112) 1 mL   915-027 $285.00
Background
Neuron-specific neurofilaments belong to the intermediate filament protein family, also known as 10nm filaments. As major constituents of the axonal cytoskeleton, neurofilaments contain heteropolymers of three major proteins: 200 kDa heavy molecular weight protein NF-H, 160 kDa medium molecular weight protein NF-M, and 68 kDa light molecular weight protein NF-L, with the ratio of each changing during neuronal development. All three proteins contain globular head and tail domains flanking a central alpha-helical domain. An accumulation of neurofilament proteins and/or mutations in one of the three major proteins occur during the progression of numerous neurological diseases, including ALS.

Table of Abbreviations

Applications
IHC

Species Reactivity
B

Conjugate

Isotype
IgG1

Purification
Protein A Affinity

Immunogen
Bovine Neurofilament

Host
Mouse

Clone Number
DP5-112

Source
Mouse mAb

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
Neurofilament (NF-H) Polyclonal Antibody
NBA-137E
Neurofilament (NF-M) Monoclonal Antibody (3H11)
NBA-140E

Citations
Launch Citation Database

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