Nicastrin Polyclonal Antibody

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Description Size Catalog# Price Quantity  
Nicastrin Polyclonal Antibody 100 µg   905-737-100 $255.00
Background
Nicastrin, in addition to presenilin, PEN2, and APH-1, forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors, and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer?s disease.

Table of Abbreviations

Applications
WB

Species Reactivity
H, M, R

Conjugate

Isotype
not applicable

Product Image(s): click to enlarge

Purification
Peptide Affinity

Immunogen
Synthetic peptide corresponding to sequence near the carboxy-terminus of human Nicastrin

Host
Rabbit

Clone Number
not applicable

Positive Control
mouse brain

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
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beta-Amyloid Monoclonal Antibody (2C8)
NBA-104E

Citations
Launch Citation Database

Ordering Info
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