Osteopontin Monoclonal Antibody (53)

Brand: Assay Designs Print Page
Description Size Catalog# Price Quantity  
Osteopontin Monoclonal Antibody (53) 100 µg   905-629 $270.00
Background
Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to provide prognostic information in breast, prostate, colon, and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.

Table of Abbreviations

Applications
EIA, IHC, WB

Species Reactivity
H

Conjugate

Isotype
IgG2a

Purification
Protein G Affinity

Immunogen
Recombinant human Osteopontin

Host
Mouse

Clone Number
53

PositiveControls
breast cancer

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
OPG Monoclonal Antibody (98A1071)
AAM-020E
Osteopontin (human) EIA Kit
900-142
Osteopontin (rodent) EIA Kit
900-090A
Osteopontin Polyclonal Antibody
905-500

Citations
Launch Citation Database

Ordering Info
Click here to learn more about online ordering
 Order by phone: 734-668-6113 or 877-423-4548
Order by e-mail: orders@assaydesigns.com
Order by fax: 734-669-0134