Osteopontin Polyclonal Antibody

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Description Size Catalog# Price Quantity  
Osteopontin Polyclonal Antibody   1.0 mL 905-500 $295.00  
Background
Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to be a positive indicator of colon and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.

Table of Abbreviations

Applications
IHC, WB

Species Reactivity
H, P, C

Conjugate

Isotype
not applicable

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from the internal domain of human OPN

Host
Rabbit

Clone Number
not applicable

Product Image(s): click to enlarge

For research use only, not for diagnostic or therapeutic use.

Documentation
CofA_905-500_LOT-06200814
Spec Sheet

Product Manual

Product Name Catalog # Manual
Osteopontin Polyclonal Antibody 905-500   Spec Sheet    

Related Products

Product Name Catalog#
Osteopontin (human) EIA Kit
900-142
Osteopontin (rodent) EIA Kit
900-090A
Osteopontin Monoclonal Antibody (53)
905-629
Osteopontin Monoclonal Antibody (87-B)
905-630

Citations
Launch Citation Database

Ordering Info
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