Calreticulin Polyclonal Antibody

Brand: Stressgen

Print Page

Description	Size	Catalog#	Price	Quantity
Calreticulin Polyclonal Antibody	50 痢	SPA-602D	$130.00
Calreticulin Polyclonal Antibody	200 痢	SPA-602F	$310.00

Background

The multifunctional, multi-compartmental protein Calreticulin (Crt) functions as a soluble molecular chaperone of new or misfolded proteins as well as a Ca2+-binding protein. Most abundant in the ER lumen, Crt expression also occurs in other membrane-bound organelles, the cell surface, and extracellularly. Also known as CRP-55, calregulin and HACBP (high affinity calcium-binding protein), Crt contains the ER-retrieval sequence, KDEL, and is the soluble paralog of the ER membrane protein Calnexin (Cnx). Crts three domains include a 180 residue N-terminal domain, a proline-rich P-domain (residues 189-288) that binds Ca2+ with high affinity and shares homology with Cnx and calmegin, and a 110 residue C-terminal domain that binds Ca2+ with low affinity but high capacity. The P-domain may interact with the co-chaperone ERp57 (Grp58), a thiol reductase. The NMR structure of the P-domain consists of an extended hairpin that appears to form a curved protrusion from the Crt core domain. Both Crt and its membrane bound homolog CNX interact with proteins and glycoproteins possessing monoglucosylated N-glycans. The Crt/Cnx cycle promotes correct folding, inhibits aggregation of folding intermediates, blocks premature oligomerization, regulates ER degradation, and prevents incompletely folded glycoproteins from exiting to the Golgi complex. Crt also appears to function as an auto-antigen in systemic lupus erythematosus, rheumatoid arthritis, celiac disease, complete congenital heart block, and halothane hepatitis. A diversity of additional functions attributed to Crt includes adhesion, blood function, and cardiac and neuronal development gene expression.

Table of Abbreviations

Applications
WB

Species Reactivity
H, M, R

Conjugate

Isotype
not applicable

Purification
Protein A Affinity

Immunogen
Recombinant Human Calreticulin

Host
Rabbit

Clone Number
not applicable

Product Image(s): click to enlarge

For research use only, not for diagnostic or therapeutic use.

Documentation
CofA_SPA-602_LOT-02200927
MSDS
Spec Sheet

Product Manual

Product Name	Catalog #	Manual
Calreticulin Polyclonal Antibody	SPA-602D
Calreticulin Polyclonal Antibody	SPA-602F

Related Products

Product Name	Catalog#
Calcineurin A Polyclonal Antibody	SPA-610
Calcineurin A Polyclonal Antibody	SPA-610D
Calcineurin A Polyclonal Antibody	SPA-610F
Calnexin (lumenal domain) Recombinant Human Protein	SPP-865
Calnexin (lumenal domain) Recombinant Human Protein	SPP-865F
Calnexin (lumenal domain) Recombinant Human Protein	SPP-865D
Calreticulin (CALR) Monoclonal Antibody (1G11-1A9)	H00000811-M01
Calreticulin (CALR3) Monoclonal Antibody (4E3)	H00125972-M01
Calreticulin Monoclonal Antibody (FMC 75)	SPA-601
Calreticulin Monoclonal Antibody (FMC 75)	SPA-601F
Calreticulin Monoclonal Antibody (FMC 75)	SPA-601D
Calreticulin Monoclonal Antibody (FMC 75), DyLight 488	SPA-601-488
Calreticulin Monoclonal Antibody (FMC 75), DyLight 488	SPA-601-488D
Calreticulin Monoclonal Antibody (FMC 75), DyLight 488	SPA-601-488F
Calreticulin Monoclonal Antibody (FMC 75), PE	SPA-601PE
Calreticulin Monoclonal Antibody (FMC 75), PE	SPA-601PED
Calreticulin Monoclonal Antibody (FMC 75), PE	SPA-601PEF
Calreticulin Polyclonal Antibody	SPA-600
Calreticulin Polyclonal Antibody	SPA-603D
Calreticulin Polyclonal Antibody	SPA-602F
Calreticulin Polyclonal Antibody	SPA-602D
Calreticulin Polyclonal Antibody	SPA-602
Calreticulin Polyclonal Antibody	SPA-603F
Calreticulin Polyclonal Antibody	SPA-603
Calreticulin Polyclonal Antibody	SPA-600F
Calreticulin Polyclonal Antibody	SPA-600J
Calreticulin Polyclonal Antibody	SPA-600D
Calreticulin Recombinant Human Protein	SPP-600
Calreticulin Recombinant Human Protein	SPP-600D
Calreticulin Recombinant Human Protein	SPP-600F

Citations
Launch Citation Database

Ordering Info
Click here to learn more about online ordering
Order by phone: 734-668-6113 or 877-423-4548
Order by e-mail: orders@assaydesigns.com
Order by fax: 734-669-0134

Browse by

Calreticulin Polyclonal Antibody