BACE2 (NT) Polyclonal Antibody

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Description Size Catalog# Price Quantity  
BACE2 (NT) Polyclonal Antibody 100 µg   905-290 $235.00
Background
Accumulation of the amyloid-beta (Abeta) plaque, which is linked with the pathogenesis of Alzheimer?s disease, is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99 amino acid carboxy-terminal fragment (C99). beta-secretase was identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and Aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with approximately

Table of Abbreviations

Applications
WB

Species Reactivity
H, M, R

Conjugate

Isotype
not applicable

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from sequence near the amino-terminus of human BACE2

Host
Rabbit

Clone Number
not applicable

Product Image(s): click to enlarge

PositiveControls
Human brain tissue lysates

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

Ordering Info
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