AIF (IN) Polyclonal Antibody

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Description Size Catalog# Price Quantity  
AIF (IN) Polyclonal Antibody 100 µg   905-168 $285.00
Background
Apoptosis inducing factor (AIF) is a mitochondrial inter-membrane flavoprotein that is ubiquitously expressed both in normal tissues and in a variety of cancer cell lines. AIF is synthesized as a nonapoptogenic precursor in the cytoplasm and efficiently imported into the mitochondrial inter-membrane space. Mature AIF protein is normally confined to the mitochondrial inter-membrane space. In a variety of different apoptosis-inducing conditions AIF translocates through the outer mitochondrial membrane to the cytosol and to the nucleus. Extra-mitochondrial AIF induces nuclear chromatin condensation and large scale (~50kb) DNA fragmentation.

Table of Abbreviations

Applications
IHC, WB

Species Reactivity
H, M, R

Conjugate

Isotype
not applicable

Product Image(s): click to enlarge

Purification
Ion Exchange

Immunogen
Synthetic peptide derived from the sequence of human AIF

Host
Rabbit

Clone Number
not applicable

For research use only, not for diagnostic or therapeutic use.

Documentation
CofA_905-168_LOT-06040818
Spec Sheet

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Citations
Launch Citation Database

Ordering Info
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