DcR3/TR6 (NT) Polyclonal Antibody

Brand: Assay Designs Print Page
Description Size Catalog# Price Quantity  
DcR3/TR6 (NT) Polyclonal Antibody 100 µg   905-219 $235.00
Background
Decoy receptors (DcRs) are signaling-deficient receptors for certain members of the TNF family of cytokines, including TRAIL/Apo2L and FasL. Functional TRAIL receptors such as DR4 and DR5 transmit apoptotic signals via their intracellular death domains. In contrast, three identified TRAIL decoy receptors (DcR1, DcR2, and osteoprotegerin/OPG) completely or partially lack the signaling death domain, and/or are secreted from cells and unable to transmit intracellular signals. Thus, expression of DcRs promotes survival by sequestration of apoptotic ligands. A fourth identified decoy receptor, DcR3, binds both FasL and the vascular endothelial cell growth inhibitor (VEGI), inhibiting Fas and DR3 death signals.

Table of Abbreviations

Applications
IHC, WB

Species Reactivity
H, M, R

Conjugate

Isotype
not applicable

Purification
Ion Exchange

Immunogen
Synthetic peptide derived from sequence near the amino-terminus of human DcR3 precursor

Host
Rabbit

Clone Number
not applicable

Product Image(s): click to enlarge

PositiveControls
Tissue lysate of human heart

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
DcR1 (ED) Polyclonal Antibody
905-216
DcR3 Monoclonal Antibody (37A565)
AAM-380E

Citations
Launch Citation Database

Ordering Info
Click here to learn more about online ordering
 Order by phone: 734-668-6113 or 877-423-4548
Order by e-mail: orders@assaydesigns.com
Order by fax: 734-669-0134