Complement C4a des Arg (human) EIA Kit

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Description Size Catalog# Price Quantity  
Complement C4a des Arg (human) EIA Kit   1x96 well 900-059 $470.00  
Complement C4a des Arg (human) EIA Kit   5x96 well 901-059 $1,745.00  
Background
Activation of the complement cascade is initiated by multiple pathways, including C1q binding of antigen-antibody complexes on pathogens (classical pathway), binding of serum lectin to pathogen-unique mannose residue patterns (MBL pathway), or the spontaneous hydrolysis of C3 and subsequent processing to C3 convertase (alternative pathway). C3a and C4a are two complement cleavage products of 77- and 76-amino acid residues, respectively, that are liberated into the bloodstream and processed to their more stable metabolites C3a des Arg and C4a des Arg. Although both fragments have anaphylactic properties, C3a is considered a more potent stimulator of smooth muscle cell contraction, histamine release, and inflammation than C4a. Complement activation is associated with sepsis, respiratory distress syndrome, multi-organ failure, and transplant organ rejection.

Table of Abbreviations

Applications
EIA

Species Reactivity
H

Features

  • Non-radioactive measurement of C4a des Arg
  • Sample prep reagents are provided

Range
0.78 - 200 ng/mL

Sample Size
100 µL

Product Image(s): click to enlarge

Cross Reactivities
C4a des Arg 100%
C4 2.14%
C5a des Arg 0.28%
C3 0.23%
C3a des Arg 0.04%
C5 0.02%

Sample Types
plasma

Samples Per Kit
39 in duplicate per 96 well kit

Sensitivity
0.76 ng/mL

Time To Answer
3 hours

For research use only, not for diagnostic or therapeutic use.

Documentation
AssayLayout

Product Manual

Product Name Catalog # Manual
Complement C4a des Arg (human) EIA Kit 900-059   Kit Insert     MSDS    
Complement C4a des Arg (human) EIA Kit 901-059   Kit Insert     MSDS    

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Citations
Launch Citation Database

Ordering Info
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