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Hsc70 (Hsp73) Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsc70 (Hsp73) Polyclonal Antibody   50 µg SPA-819D $135.00  
Hsc70 (Hsp73) Polyclonal Antibody   200 µg SPA-819F $325.00  
Background
The 70 kDa heat shock protein Hsp70 belongs to the Hsp70 family of highly-related protein isoforms ranging in size from 66 kDa to 78 kDa. Hsc70 shares close biochemical and biological ties to Hsp70, and also belongs to the Hsp70 family. These proteins include cognate members found within major intracellular compartments and highly inducible isoforms predominantly cytoplasmic or nuclear in distribution. Members of the Hsp70 family function as molecular chaperones involved in such cellular functions as protein folding, transport, maturation and degradation, operating in an ATP-dependent manner. The molecular chaperones of the Hsp70 family recognize and bind to nascent polypeptide chains or partially folded intermediates of proteins, preventing their aggregation and misfolding, and the binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein. Data demonstrates that with a ubiquitin-like domain at its amino terminus and its association with the 26S proteosome in HeLa cells, Bag-1 modulates the chaperone activity of Hsc70 and Hsp70. These findings reveal Bag-1's role as a physical link between the Hsc70/Hsp70 chaperone system and the proteasome. Experimental data also shows that the ATPase domain and the substrate binding domain of Hsd70 cooperate to form a co-chaperone-chaperone complex with the synaptic vesicle cysteine string protein (csp), essential for normal neurotransmitter release.

Table of Abbreviations

Applications
WB

Species Reactivity
H, M, R

Conjugate

Isotype
not applicable

Purification
Protein A Affinity

Immunogen
Synthetic peptide derived from the sequence near the carboxy terminus of human Hsc70 (Hsp73), conjugated to ovalbumin; sequence identical to rat, mouse, bovine, canine, chicken, monkey, and frog

Host
Rabbit

Clone Number
not applicable

Product Image(s): click to enlarge

Source
Rabbit pAb

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsc70 (Hsp73) Polyclonal Antibody SPA-819D  
Hsc70 (Hsp73) Polyclonal Antibody SPA-819F  

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Citations
Launch Citation Database

Ordering Info
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