TIF1 beta Monoclonal Antibody (20A1)

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
TIF1 beta (20A1) Monoclonal Antibody  200 µg KAM-TF200F $340.00  
TIF1 beta (20A1) Monoclonal Antibody  50 µg KAM-TF200D $160.00  
Background
Transcriptional intermediary factors (TIFs) are a group of transcriptional coactivators and corepressors that regulate gene expression by modulating chromatin structure and assembly of transcription initiation complexes. TIF1 beta (also known as KAP-1 or KRIP-1) is a member of the TIF1 subfamily of chromatin-associated TIFs that play a key role in many developmental and physiological processes. The three mammalian TIF1 proteins (TIF1 alpha, beta and gamma) share three conserved domains. An N-terminal RING-B box coiled coil (RBCC) domain most likely attributes to intermolecular structure, while two characteristic chromatin-targeting domains, a plextrin homology (PH) finger motif and bromodomain, are found in the C-terminus. TIF1 beta acts as a transcriptional repressor by modulating histone deacetlyation, histone H3 Ly-9 methylation, and recruitment of HP1 proteins. TIF1 beta was shown to form homo-oligomers in vitro, but does not form hetero-oligomers with TIF1 alpha or TIF1 gamma.

Table of Abbreviations

Abbreviated Name
TIF1 beta mAb (20A1)

Conjugate

Applications
WB

Isotype
IgG1

Purification
Protein G Affinity

Immunogen
Recombinant protein covering the N-terminal half of human TIF1¦Â

Host
Mouse

Clone Number
20A1

Product Image(s): click to enlarge

Species Reactivity
H

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
Spec Sheet

Product Manual

Product Name Catalog # Manual
TIF1 beta (20A1) Monoclonal Antibody KAM-TF200F  
TIF1 beta (20A1) Monoclonal Antibody KAM-TF200D  

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Citations
Launch Citation Database

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