Leptin (human) EIA Kit

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Description Size Catalog# Price Quantity  
Leptin (human) EIA Kit 1x96 well   900-028A $425.00
Background
The adipokine leptin is a hormone secreted predominantly by adipose tissue that signals through leptin receptors in the hypothalamus to decrease appetite and increase energy expenditure. Binding of leptin to the long-form of the leptin receptor in the hypothalamus reduces neuropeptide Y (NPY) and agouti-related protein (AgRP) activity, while stimulating anorexigenic pro-opiomelanocortin (POMC) neuron activity to reduce appetite. In peripheral tissues, leptin antagonizes insulin signaling, increases fatty acid oxidation, decreases insulin production in pancreatic beta cells, and promotes fertility. Its expression in adipocytes can be regulated in a paracrine fashion by other adipokines such as IL-6 (stimulation) and TNF-alpha (inhibition). Leptin deficient mice display severe insulin resistance, obesity, and decreased fertility, all of which are reversible by administration of exogenous leptin. In contrast, elevated circulating levels of leptin are associated with increased obesity, indicative of an acclimated state of leptin resistance which is not well understood.

Table of Abbreviations

Applications
EIA

Species Reactivity
H

Features

  • Sensitive - accurately quantify as little as 23.4 pg/mL
  • Save time - obtain results from 39 samples in duplicate in just 3 hours!
  • Convenient- store all reagents at 4ēC

Cross Reactivities
Human Leptin 100% / Mouse & Rat Leptin <0.01%

Range
31.3 - 2,000 pg/mL

Product Image(s): click to enlarge

Sample Types
CS, P, S

Samples Per Kit
39 in dupliate

Sensitivity
23.4 pg/mL

Time To Answer
3 hours

For research use only, not for diagnostic or therapeutic use.

Documentation
Kit Insert
Technical Bulletin

Related Products

Product Name Catalog#
Leptin (human) Monoclonal Antibody
ABS 022-03
Leptin (human) Monoclonal Antibody
ABS 022-06
Leptin (human) Monoclonal Antibody
ABS 022-11
Leptin (human) Monoclonal Antibody, Biotin
ABS 022-11B
Leptin (mouse) EIA Kit
900-019A
Leptin (rat) EIA Kit
900-015A

Citations
Launch Citation Database

Ordering Info
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