Hsp70-A1 Recombinant Mouse Protein

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp70-A1 Recombinant Mouse Protein   50 µg SPP-502D $180.00  
Hsp70-A1 Recombinant Mouse Protein   200 µg SPP-502F $430.00  
Background
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Table of Abbreviations

Applications
ATPase Activity Assay, WB Control

Species Reactivity
Not applicable

Expression System
Recombinant mouse Hsp70-A1 expressed in E. coli.

Purification
> 90 % pure as determined by SDS-PAGE and Western blot analyses This protein does not contain DnaK as demonstrated by western blot analysis using product SPA-880.

Source
Mouse

Product Image(s): click to enlarge

For research use only, not for diagnostic or therapeutic use.

Documentation
CofA_SPP-502_LOT-09010911
MSDS
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsp70-A1 Recombinant Mouse Protein SPP-502D  
Hsp70-A1 Recombinant Mouse Protein SPP-502F  

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Citations
Launch Citation Database

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