Endothelin-A (ET-A) Receptor Polyclonal Antibody

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Description Size Catalog# Price Quantity  
Endothelin-A (ET-A) Receptor Polyclonal Antibody 100 µg  915-007 $295.00
Background
Endothelins (ET) are isopeptides produced by vascular endothelium that have potent vasoconstrictive activity. The peptides are encoded by three separate genes and processed to yield 39-residue "Big ET" molecules which are further processed to the 21 amino acid sequences designated ET-1, ET-2 and ET-3. ET action is mediated via binding to two receptors, ETA and ETB. Activation of ETA increases vasoconstriction and sodium retention, thereby increasing blood pressure. Activation of ETB receptors triggers the release of vasorelaxive factors such as nitric oxide (NO) and prostanoids from endothelial cells and increases urine production and elimination, thereby lowering blood pressure.

Table of Abbreviations

Applications
IHC, WB

Product Image(s): click to enlarge

Immunogen
Synthetic peptide derived from sequence near the carboxy-terminus of Human ET-A receptor

Source
Rabbit pAb

Species Reactivity
H, B, R

Purification Method
Peptide affinity

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
Big Endothelin-1 (human) EIA Kit
 		900-022
Endothelin-1 (human) EIA Kit
 		900-020
Endothelin-1 EIA Kit
 		900-020A
Endothelin-A (ET-A) Receptor Polyclonal Antibody
 		915-006
Endothelin-B (ET-B) Receptor (B27) Polyclonal Antibody
 		915-008
Endothelin-B (ET-B) Receptor Monoclonal Antibody (8Z11)
 		905-637

Citations
Launch Citation Database

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