Neurofilament Monoclonal Antibody (DP5-112)

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Description Size Catalog# Price Quantity  
Neurofilament Monoclonal Antibody (DP5-112) 1 mL  915-027 $295.00
Background
Neuron-specific neurofilaments belong to the intermediate filament protein family, also known as 10nm filaments. As major constituents of the axonal cytoskeleton, neurofilaments contain heteropolymers of three major proteins: 200 kDa heavy molecular weight protein NF-H, 160 kDa medium molecular weight protein NF-M, and 68 kDa light molecular weight protein NF-L, with the ratio of each changing during neuronal development. All three proteins contain globular head and tail domains flanking a central alpha-helical domain. An accumulation of neurofilament proteins and/or mutations in one of the three major proteins occur during the progression of numerous neurological diseases, including ALS.

Table of Abbreviations

Applications
IHC

Immunogen
Bovine Neurofilament

Source
Mouse mAb

Species Reactivity
B

Purification Method
Protein A Affinity

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
Neurofilament NF-H Polyclonal Antibody
 		NBA-137E
Neurofilament NF-M Monoclonal Antibody (3H11)
 		NBA-140E

Citations
Launch Citation Database

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