nNOS (phospho-Ser1417) Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
nNOS (phospho-Ser1417) Polyclonal Antibody   50 µg KAP-NO032D $190.00  
nNOS (phospho-Ser1417) Polyclonal Antibody   200 µg KAP-NO032F $370.00  
Background
The diffusible free radical gas nitric oxide (NO) affects a variety of physiological functions, and is a key regulator of the cardiovascular, nervous, and immune systems. NO is synthesized in many tissues from L-arginine, oxygen, and NADPH by three known isoforms of a heme-containing flavoprotein termed NO synthase (nNOS/NOS-I, iNOS/NOS-II, and eNOS/NOS-III). nNOS is a constitutively expressed neuronal NOS isoform that exits in its latent form until it is activated by the binding of calmodulin follo wing elevation of intracellular calcium levels. The C-terminus of nNOS contains a conserved serine residue, Ser1417, analogous to Ser1177 of the constitutively expressed endothelial NOS isoform (eNOS). Phosphorylation of Ser1417 is believed to regulate nNOS activation, particularly in glucose-sensing neurons, where inhibition of AMPK pathways by glucose and leptin serve to suppress nNOS activity, whereas activation of AMPK by insulin leads to nNOS activation.

Table of Abbreviations

Applications
WB

Species Reactivity
H

Conjugate

Isotype
not applicable

Source
Rabbit pAb

Product Image(s): click to enlarge

Purification
Peptide Affinity

Immunogen
Synthetic phospho-peptide derived from the sequence near the carboxy-terminus of human nNOS

Host
Rabbit

Clone Number
not applicable

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
Spec Sheet

Product Manual

Product Name Catalog # Manual
nNOS (phospho-Ser1417) Polyclonal Antibody KAP-NO032D  
nNOS (phospho-Ser1417) Polyclonal Antibody KAP-NO032F  

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Citations
Launch Citation Database

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