Hsp90 Monoclonal Antibody (AC88), DyLight(TM) 488 Conjugate

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp90 Monoclonal Antibody (AC88), DyLight(TM) 488 Conjugate  100 µg SPA-830-488E $325.00  
Background
The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

Table of Abbreviations

Conjugate
DyLight 488

Applications
Flow

Isotype
IgG1

Purification
Protein G Affinity

Immunogen
Achlya ambisexualis (water mold) Hsp90 protein

Host
Mouse

Clone Number
AC88

Species Reactivity
H, M, R, BE, C, CE, CH, F

For research use only, not for diagnostic or therapeutic use.

Documentation

Product Manual

Product Name Catalog # Manual
Hsp90 Monoclonal Antibody (AC88), DyLight(TM) 488 Conjugate SPA-830-488E   Spec Sheet   

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Citations
Launch Citation Database

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