HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 ), Biotin Conjugate

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Description Size Catalog# Price Quantity  
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2), Biotin Conjugate  100 µg OSA-111BE $345.00  
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2), Biotin Conjugate  25 µg OSA-111BC $175.00  
Background
Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

Table of Abbreviations

CloneNumber
HO-1-2

HostSpecies
mouse

Immunogen
Native rat HO-1 protein

PositiveControls
HO-1 (Hsp32) Protein, SPP-730

Applications
EIA, ICC, IHC, WB

Species Reactivity
H, M, R, C, GR, GP, HA, MO, P, RB

For research use only, not for diagnostic or therapeutic use.

Documentation

Product Manual

Product Name Catalog # Manual
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2), Biotin Conjugate OSA-111BE   TechSpec   
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2), Biotin Conjugate OSA-111BC   TechSpec   

Related Products

Product Name Catalog#
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 ), FITC Conjugate
 		OSA-111FI
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2), PE Conjugate
 		OSA-111PE
Heme Oxygenase-1 Monoclonal Antibody (HO-1-2), DyLight(TM) 488 Conjugate
 		OSA-111-488

Citations
Launch Citation Database

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