HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 ), FITC Conjugate

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Description Size Catalog# Price Quantity  
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2), FITC Conjugate  50 µg OSA-111FID $150.00  
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2), FITC Conjugate  200 µg OSA-111FIF $350.00  
Background
Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

Table of Abbreviations

Conjugate
FITC

Applications
Flow

Isotype
IgG2b

Purification
Protein G Affinity

Species Reactivity
H, M, R, C, GP, HA, MO

Immunogen
Native rat HO-1 (Hsp32) protein

Host
Mouse

Clone Number
HO-1-2

PositiveControls
HO-1 (Hsp32) Protein, SPP-730

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
Spec Sheet

Product Manual

Product Name Catalog # Manual
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2), FITC Conjugate OSA-111FID  
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2), FITC Conjugate OSA-111FIF  

Related Products

Product Name Catalog#
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 )
 		OSA-111
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 ), Biotin Conjugate
 		OSA-111B
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2), PE Conjugate
 		OSA-111PE
HO-1 (Hsp32) Recombinant Protein
 		SPP-732
HO-1 (Hsp32) Recombinant Protein
 		SPP-730
HO-1 (Human) ELISA Kit
 		EKS-800
HO-1 (Rat) ELISA Kit
 		EKS-810A
Heme Oxygenase-1 Monoclonal Antibody (HO-1-2), DyLight(TM) 488 Conjugate
 		OSA-111-488

Citations
Launch Citation Database

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