Thapsigargin, ER Inhibitor

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Description Size Catalog# Price Quantity  
Thapsigargin, ER Inhibitor 1 mg   908-298 $60.00
Background
Thapsigargin is a sesquiterpene lactone, and is a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ -ATPase (SERCA). Treatment with thapsigargin results in an increase in cytosolic calcium levels due to release of intracellular calcium stores, and is characterized as a weak skin tumor promoter in mice. Depletion of ER calcium stores leads to Ca2+ influx via activation of store-operated calcium channels in the plasma membrane, mediating physiological functions such as exocytosis, muscle contraction, sperm chemotaxis, gene transcription, cell division, and apoptosis.

Table of Abbreviations

Applications
Inhibits SERCA; Induces UPR

Species Reactivity
Species Independent

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

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