Nicastrin Polyclonal Antibody

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Description Size Catalog# Price Quantity  
Nicastrin Polyclonal Antibody 100 µg  905-737-100 $255.00
Background
Nicastrin, in addition to presenilin, PEN2, and APH-1, forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors, and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer?s disease.

Table of Abbreviations

Applications
WB

Product Image(s): click to enlarge

Species Reactivity
H, M, R

Format
PBS, 0.02% sodium azide

Host Species
Rabbit

Immunogen
Synthetic peptide corresponding to a sequence near the carboxy-terminus of human Nicastrin

Positive Control
mouse brain

Purification Method
Peptide Affinity

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
APP Monoclonal Antibody (3E9)
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Amyloid beta Monoclonal Antibody (2C8)
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PEN2 Polyclonal Antibody
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Citations
Launch Citation Database

Ordering Info
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