IRE1p Polyclonal Antibody

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Description Size Catalog# Price Quantity  
IRE1p Polyclonal Antibody 100 µg  905-727-100 $295.00
Background
Accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and upregulation of the ER molecular chaperones GRP78 and GRP94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress induces their dissociation. This allows IRE1p, a serine-threonine protein kinase, to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also functions as an endoribonuclease to splice X-box binding protein (XBP1) mRNA, converting it to a potent UPR transcriptional activator.

Table of Abbreviations

Abbreviated Name
IRE1p pAb

Conjugate

Applications
ICC, WB

Isotype
not applicable

Product Image(s): click to enlarge

Purification
Peptide Affinity

Species Reactivity
H, M, R

Immunogen
Synthetic peptide corresponding to sequence near the carboxy-terminus of human IRE1p

Host
Rabbit

Clone Number
not applicable

Positive Control
A20 cell lysates

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

Ordering Info
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