MET/HGFR (phospho-Tyr1234/1235) Monoclonal Antibody (6AT1877)

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Description Size Catalog# Price Quantity  
MET/HGFR (phospho-Tyr1234/1235) Monoclonal Antibody (6AT1877) 100 µg  905-696-100 $295.00
Background
c-Met/HGFR is a receptor tyrosine kinase that binds hepatocyte growth factor (HGF). Binding of HGF to c-Met triggers receptor dimerization and phosphorylation on multiple residues within the juxtamembrane, catalytic core, and cytoplasmic tail domains, thereby regulating receptor internalization, catalytic activity, and multisubstrate docking. c-Met contains three tyrosines (Tyr1230/1234/1235) within the activation loop of the catalytic domain that regulate receptor activation. c-Met is overexpressed in a significant percentage of human cancers and is amplified during the transition between primary tumors and metastasis.

Table of Abbreviations

Conjugate

Applications
EIA

Isotype
IgG1

Purification
Peptide Affinity

Immunogen
Synthetic (phosphorylated) peptide corresponding to sequences in Tyr1234/1235 region of human MET, conjugated to KLH

Host
Mouse

Clone Number
6AT1877

Species Reactivity
H, M

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

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HGF/SF Monoclonal Antibody (7-2)
 		905-165
HGF/SF Monoclonal Antibody (A10)
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c-Met (phospho-Tyr1230/1234/1235) Polyclonal Antibody
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c-Met Polyclonal Antibody
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Citations
Launch Citation Database

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