Hsp27 (phospho) Recombinant Protein

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp27 (phospho) Recombinant Protein  50 µg SPP-716D $170.00  
Background
Hsp27 is one of the most common members of the highly conserved and ubiquitously expressed family of small heat shock proteins (sHsp), which also includes alphaB-crystallin. It is characterized by a conserved C-terminal alpha-crystallin domain consisting of two anti-parallel beta-sheets that promote oligomer formation required for its primary chaperone function as inhibitor of irreversible protein aggregation. Hsp27 oligomerization is modulated by post-translational phosphorylation of Hsp27 at three serine residues, Ser15, Ser78, and Ser82, by a variety of protein kinases including MAPKAPK-3, PKAc-alpha, p70 S6K, PKD I, and PKC-delta. Hsp27 has been shown to inhibit actin polymerization by binding of unphosphorylated Hsp27 monomers to actin intermediate filaments. Anti-apoptotic functions of Hsp27 have also been identified through interactions with DAXX7, activation of Akt, and inhibition of apoptosome formation. Evidence suggests altered expression of Hsp27 is implicated in the pathogenesis of breast, ovarian, and prostate cancer.

Table of Abbreviations

Expression System
Recombinant human Hsp27 expressed in E. coli and phosphorylated

Species Reactivity
not applicable

Applications
WB Control, EIA

Purification
Multi-step chromatography

Source
Human

Positive Control
SPA-523 Hsp27 (phospho-Ser78) polyclonal antibody, SPA-524 Hsp27 (phospho-Ser82) polyclonal antibody, and SPA-525 Hsp27 (phospho-Ser15) polyclonal antibody.

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsp27 (phospho) Recombinant Protein SPP-716D  

Related Products

Product Name Catalog#
Hsp27 (phospho-Ser15) EIA Kit
 		900-170
Hsp27 (phospho-Ser78) EIA Kit
 		900-165
Hsp27 (phospho-Ser78) Polyclonal Antibody
 		SPA-523
Hsp27 (phospho-Ser82) Monoclonal Antibody (5B9)
 		905-642
Hsp27 (phospho-Ser82) Polyclonal Antibody
 		SPA-524
Hsp27 ELISA Kit
 		EKS-500
Hsp27 Recombinant Protein
 		SPP-715
Hsp27 Recombinant Protein - Low Endotoxin
 		ESP-715

Citations
Launch Citation Database

Ordering Info
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