Caspase 2 Monoclonal Antibody (4-1-5)

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Description Size Catalog# Price Quantity  
Caspase 2 Monoclonal Antibody (4-1-5) 100 µg  905-685-100 $295.00
Background
The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or ?executioner? caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.

Table of Abbreviations

Applications
WB

Format
PBS, pH 7.2, 0.09% azide, in 50% glycerol.

Product Image(s): click to enlarge

Host Species
Mouse

Immunogen
Recombinant full length human Caspase-2

Positive Control
Human (Jurkat cells +/- staurosporine)

Purification Method
Protein G Affinity

Species Reactivity
H

Clone
4-1-5

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

Ordering Info
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