PDGF Receptor beta Monoclonal Antibody (42G12)

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Description Size Catalog# Price Quantity  
PDGF Receptor beta Monoclonal Antibody (42G12) 100 µg  905-682-100 $250.00
Background
Mitogenic platelet derived growth factor (PDGF) signaling is mediated by the PDGF tyrosine kinase receptors PDGFRalpha and PDGFRbeta, which exist as homo- or heterodimer isoforms (alphaalpha, betabeta, alphabeta). Secretion of PDGFs and expression of PDGFRs in a broad distribution of cell types contributes to regulation of cellular processes including cell growth, actin reorganization, prevention of apoptosis, and chemotaxis. Structurally, the transmembrane PDGFRs are composed of an N-terminal extracellular domain with five immunoglobulin repeats, and an intracellular domain containing two spaced tyrosine kinase domains. PDGF ligands display preferential affinity to PDGFRalpha and PDGFRbeta, with PDGFRbeta activation restricted to binding by PDGF BB and PDGF DD. Growth factor binding initiates receptor dimerization and activates the cytosolic tyrosine kinase domains.

Table of Abbreviations

Abbreviated Name
PDGF Receptor beta mAb (42G12)

Conjugate

Applications
WB

Isotype
IgG1

Product Image(s): click to enlarge

Purification
Protein G Affinity

Immunogen
Recombinant human PDGF Receptor beta Protein

Host
Mouse

Clone Number
42G12

Positive Control
Mouse (heart), Rat (heart), Human (heart- weakly reactive)

Species Reactivity
H, M, R

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

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