mTOR Polyclonal Antibody

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Description Size Catalog# Price Quantity  
mTOR Polyclonal Antibody 100 µg  905-687-100 $295.00
Background
Mammalian target of rapamycin (mTOR) is an atypical serine-threonine protein kinase and member of the phosphatidylinositol 3-kinase (PI3K) signaling pathway. TORC1 (mTOR, GbetaL/mLST8 and Raptor) and TORC2 (mTOR, GbetaL/mLST8, SIN1, and Rictor) complexes control protein synthesis through the direct or indirect phosphorylation of downstream targets such as S6 Kinase and 4EBP1, key regulators of mRNA recruitment to ribosomes. Through its involvement in several key signaling pathways and its critical role in transcription and translation, mTOR mediates cell proliferation, differentiation, and survival. Recent studies identified the TORC2 complex as the missing kinase activator of Akt/PKB, deregulation of which has been implicated in the pathogenesis of cancer and diabetes.

Table of Abbreviations

Abbreviated Name
mTOR pAb

Conjugate

Applications
WB

Isotype
not applicable

Product Image(s): click to enlarge

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from the sequence of human mTOR

Host
Rabbit

Clone Number
not applicable

Positive Control
Human (HeLa, 293-EGF) and mouse (liver)

Species Reactivity
H, M

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

Ordering Info
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