Hsp27 (phospho-Ser82) Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp27 (phospho-Ser82) Antibody  50 µL SPA-524D $160.00  
Hsp27 (phospho-Ser82) Antibody  200 µL SPA-524F $345.00  
Background
Hsp27 is one of the most common members of the highly conserved and ubiquitously expressed family of small heat shock proteins (sHsp), which also includes alphaB-crystallin. It is characterized by a conserved C-terminal alpha-crystallin domain consisting of two anti-parallel beta-sheets that promote oligomer formation required for its primary chaperone function as inhibitor of irreversible protein aggregation. Hsp27 oligomerization is modulated by post-translational phosphorylation of Hsp27 at three serine residues, Ser15, Ser78, and Ser82, by a variety of protein kinases including MAPKAPK-3, PKAc-alpha, p70 S6K, PKD I, and PKC-delta. Hsp27 has been shown to inhibit actin polymerization by binding of unphosphorylated Hsp27 monomers to actin intermediate filaments. Anti-apoptotic functions of Hsp27 have also been identified through interactions with DAXX7, activation of Akt, and inhibition of apoptosome formation. Evidence suggests altered expression of Hsp27 is implicated in the pathogenesis of breast, ovarian, and prostate cancer.

Table of Abbreviations

Conjugate

Applications
IP, WB, IF

Isotype
not applicable

Product Image(s): click to enlarge

Purification

Immunogen
Synthetic phospho-peptide derived from the sequence of human Hsp27, coupled to KLH

Host
Rabbit

Clone Number
not applicable

Species Reactivity
H, M, R, B, C, CH, GP, S

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsp27 (phospho-Ser82) Antibody SPA-524D  
Hsp27 (phospho-Ser82) Antibody SPA-524F  

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Citations
Launch Citation Database

Ordering Info
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