GSK-3beta pAb **SALE**

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Description Size Catalog# Price Quantity  
GSK-3beta pAb **SALE** 100 µg  905-679-100 $171.00
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SALE 40% off

Was $285 for 100 µg, now ONLY $171. Offer expires March 31, 2009 or until supplies last.

Glycogen Synthase Kinase 3beta (GSK-3beta) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3beta on serine 9, which prevents GSK-3beta from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3beta is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3beta. The phosphorylated serine binds to the GSK-3beta priming phosphate position and prevents binding of alternative substrates. In addition to insulin signaling, GSK-3beta participates in the Wnt signaling pathway, where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein. In the presence of Wnts, GSK-3beta is unable to phosphorylate beta-catenin, which leads to stabilization of beta-catenin. The Wnt pathway inactivates GSK-3beta via the proteins, Dishevelled and FRAT, which disrupt the interaction of GSK-3beta with axin, beta-catenin, and APC. Clinically, there is considerable interest in GSK-3beta inhibitors because they may mimic the effect of insulin or reduce the hyperphosphorylation of Tau that is observed in Alzheimer's Disease.

Table of Abbreviations

Abbreviated Name
GSK-3 beta pAb

Conjugate

Isotype
not applicable

Purification
Protein A Affinity

Immunogen
Synthetic peptide corresponding to amino acids close to the carboxyl terminus of human GSK3¦Â

Host
Rabbit

Clone Number
not applicable

For research use only, not for diagnostic or therapeutic use.

Documentation

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Jurkat Cell Lysate
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Citations
Launch Citation Database

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