eNOS Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
eNOS Polyclonal Antibody  100 µg KAP-NO002E $345.00  
Background
The diffusible free radical gas nitric oxide (NO) affects a variety of physiological functions, and is a key regulator of the cardiovascular, nervous, and immune systems. NO is synthesized in many tissues from L-arginine, oxygen, and NADPH by three known isoforms of a heme-containing flavoprotein termed NO synthase (nNOS/NOS-I, iNOS/NOS-II, and eNOS/NOS-III). nNOS is a constitutively expressed neuronal NOS isoform that exits in its latent form until it is activated by the binding of calmodulin follo wing elevation of intracellular calcium levels. The C-terminus of nNOS contains a conserved serine residue, Ser1417, analogous to Ser1177 of the constitutively expressed endothelial NOS isoform (eNOS). Phosphorylation of Ser1417 is believed to regulate nNOS activation, particularly in glucose-sensing neurons, where inhibition of AMPK pathways by glucose and leptin serve to suppress nNOS activity, whereas activation of AMPK by insulin leads to nNOS activation.

Table of Abbreviations

Abbreviated Name
eNOS pAb

Conjugate

Isotype
not applicable

Species Reactivity
H, M, R, B, P

Applications
WB, ICC, ELISA

Purification
Peptide Immunoaffinity

Immunogen
Synthetic peptide derived from the sequence corresponding to human eNOS, conjugated to KLH; sequence identical to mouse/bovine, rat, and pig

Positive Control
HeLa Cell lysate, Catalog Number LYC-HL100
Mouse Brain Tissue Extract, Catalog Number LYT-MB100
Rat Brain Tissue Extract, Catalog Number LYT-RB100

Host
Rabbit

Clone Number
not applicable

For research use only, not for diagnostic or therapeutic use.

Documentation
CofA_KAP-NO002_LOT-07220812
Spec Sheet

Product Manual

Product Name Catalog # Manual
eNOS Polyclonal Antibody KAP-NO002E  

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Mouse Brain Tissue Extract
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Nitric Oxide (total) Detection Kit
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Rat Brain Tissue Extract
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eNOS (phospho-Ser1177) Monoclonal Antibody (15E2)
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eNOS Polyclonal Antibody
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eNOS Polyclonal Antibody
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eNOS Polyclonal Antibody
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iNOS Polyclonal Antibody
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Citations
Launch Citation Database

Ordering Info
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