Shc (phospho-Tyr239/Tyr240) Monoclonal Antibody (1E3)

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Description Size Catalog# Price Quantity  
Shc (phospho-Tyr239/Tyr240) Monoclonal Antibody (1E3) 100 µg  905-666 $380.00
Background
The Src homology 2 domain containing (Shc) adaptor protein links growth factor, cytokine, and antigen receptor stimulation to the Ras signaling pathway, and plays a critical role in insulin signaling, tumorigenesis, and hematopoietic cell growth and differentiation. Structurally, Shc is composed of an N-terminal phosphotyrosine binding (PTB) domain, a medial CH1 domain, and a C-terminal SH2 domain. Upon binding to activate cell-surface receptors, Shc is phosphorylated at three tyrosine residues (Tyr239, Tyr240, Tyr317) triggering recognition of Shc by SH2-containing proteins such as Grb2.

Table of Abbreviations

Abbreviated Name
Shc phospho-Tyr239/Tyr240 mAb (1E3)

Conjugate

Isotype
IgG1

Product Image(s): click to enlarge
western blot

Applications
EIA, IHC, WB

Purification
Thiophilic adsorption and size exclusion chromatography

Immunogen
Synthetic phospho-peptide derived from the sequence of Shc, conjugated to KLH.

Host
Mouse

Clone Number
1E3

Species Reactivity
H, M, C

Positive Control
Pervandate-treated HepG2 cells

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
EGF Receptor Monoclonal Antibody (6F1)
 		CSA-330E
Shc (phospho-Tyr317) Monoclonal Antibody (15E11)
 		905-667
Shc Monoclonal Antibody (11F6)
 		905-665

Citations
Launch Citation Database

Ordering Info
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