p38 alpha Monoclonal Antibody (13D5)

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Description Size Catalog# Price Quantity  
p38 alpha Monoclonal Antibody (13D5) 100 µg  905-663 $330.00
Background
Six proteins of the p38 subfamily of MAP kinases have been identified to date, including: p38alpha (SAPK2, CSBP) and its splice variant Mxi; p38beta and beta2; p38gamma (ERK6, SAPK3); and p38delta (SAPK4). p38 MAP kinases contain a conserved TGY motif in their activation loop and are activated in response to cytokines, hormones, GPCRs, and osmotic and heat shock to mediate primarily pro-apoptotic and pro-inflammatory responses. MKK3, MKK4, and MKK6 are known to activate p38 family members with varying specificity. All four p38 isoforms are able to phosphorylate the activating transcription factor 2 (ATF2), and differentially activate numerous substrates including Mnk1/2, Msk, phospholipase A2, and the MAPKAP kinase-2 and -3. Activated MAPKAP kinase-2 subsequently phosphorylates the heat shock protein Hsp27, an F-actin binding protein involved in cytoskeletal maintenance.

Table of Abbreviations

Abbreviated Name
p38 alpha mAb (13D5)

Conjugate

Isotype
IgG1

Product Image(s): click to enlarge
western blot

Applications
EIA, IF, IP, WB

Purification
Thiophilic adsorption and size exclusion chromatography

Immunogen
Synthetic peptide derived from sequence near the amino terminus of p38alpha, conjugated to KLH

Host
Mouse

Clone Number
13D5

Species Reactivity
H, M, R, C

Positive Control
Untreated SW480 cells

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
p38 (phospho) EIA Kit
 		900-101
p38 MAPK (phospho-Thr180/Tyr182) Polyclonal Antibody
 		KAP-MA022E
p38 delta Monoclonal Antibody (5H7)
 		905-664

Citations
Launch Citation Database

Ordering Info
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