TGF-beta1 EIA Kit

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Description	Size	Catalog#	Price	Quantity
TGF-beta1 EIA Kit	1x96 well	900-155	$450.00

Background

Transforming growth factor beta 1 is also known as TGFbeta1, TGF beta, and TGFB. The inactive form consists of a TGF-¿1 homodimer that is non-covalently linked to a latency-associated peptide homodimer. The active form is a homodimer of mature TGF-beta1 that is disulfide linked. The precursor is cleaved into mature TGF-beta1 and the latency-associated peptide. Many cells can synthesize TGF-beta1, which is secreted to function in proliferation, differentiation, transformation, signaling and apoptosis. This cytokine has been implicated in many diseases including diabetes, renal disease, chronic pulmonary obstructive disease, as well as many cancers including prostate, and colon. This protein has generated tremendous excitement as a potential tumor-specific cancer therapeutic. Specifically, as a stable soluble dimer, it selectively induces apoptosis in many transformed cells but not in normal cells. The literature contains many recent reviews on the biology and function of TGF-beta1.

Table of Abbreviations

Product Image(s): click to enlarge

Applications
EIA

Range
31.25 - 1,000 pg/mL

Sample Size
100 µL

Cross Reactivites
human TGF-beta1: 100% (Assay Buffer 13 & Assay Buffer 30)
human TGF-beta1.2: 2.23% (AB13), 1.21% (AB30)
human TGF-beta2: <0.03% (AB13 & AB30)
human TGFbeta3: <0.03% (AB13 & AB30)
human latant TGF-beta1: <0.71% (AB13), <0.38% (AB30)
human LAP (latent associated protein): <0.03% (AB13 & 30)

Sample Types
cell culture supernatant, serum, plasma

Samples Per Kit
40 in duplicate

Sensitivity
3.3 pg/mL in Assay Buffer 13
10.8 pg/mL in Assay Buffer 30

Species Reactivity
H, M, R, B

Time To Answer
4 hours

For research use only, not for diagnostic or therapeutic use.

Documentation
Kit Insert

Product Manual

Product Name	Catalog #	Manual
TGF-beta1 EIA Kit	900-155

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Citations
Launch Citation Database

Ordering Info
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TGF-beta1 EIA Kit